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Image Search Results
Journal: Current biology : CB
Article Title: Divergent strategies for learning in males and females
doi: 10.1016/j.cub.2020.09.075
Figure Lengend Snippet: A) cFos gene expression (qRT-PCR) in five brain regions: nucleus accumbens (NAc), dorsal medial striatum (DMS), amygdala (AMY), hippocampus (HPC), and prefrontal cortex (PFC). Female mice showed elevated c-fos expression across all five brain regions. Extracted brain sections for each brain region are shown in the altas. B) regression coefficient of c-fos expression in NAc and PFC, and sex in predicting the use of PC2 strategy C) Heatmap of correlation matrix of c-fos expression level among five brain regions. Colorbar = Pearson’s r. D) cFos gene expression in NAc and PFC is significantly correlated with the weight of PC2. E) Median split of c-fos expression in NAc and PFC and PC2 scores within each sex. F) Sex mediated the relationship between c-fos expression in NAc and PFC and PC2 scores.The top models demonstrate thedirect effect and the bottom models demonstrate the mediated effect. Effects are labeled with estimated coefficients. The strength of the direct model is greatly reduced after mediation, suggesting that sex mediated neural measures in explaining strategy selection. See also Table S1. Graphs depict mean ± SEM. Asterisks marked significant effects (*: p < 0.05 **: p < 0.01 ***: p<0.001).
Article Snippet:
Techniques: Gene Expression, Quantitative RT-PCR, Expressing, Labeling, Selection